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Despite several advances, unresolved issues include the impact of protumorigenic and antitumorigenic mechanisms in different cell types and the mechanisms by which the antioxidant transcription factor network functions at various stages of tumorigenesis

In PCOS, the pathogenesis of ferroptosis involves not only Hepc downregulation and subsequent increases in intestinal iron absorption but also the influence of gut microbiota and their metabolites

Selenium is a key cofactor for the enzymes iodothyronine deiodinases and thyroid peroxidase (TPO)

624 In a randomized, placebo-controlled, crossover trial that included 37 participants with pre-hypertension, 160 mg quercetin daily for four weeks led to reduced inflammatory marker levels and improved a marker of endothelial function

As an important ketone body, -hydroxybutyrate has antioxidant and anti-inflammatory effects, reducing oxidative stress and protecting neurons by activating the Nrf2 signaling pathway (19, 55)

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