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Pharmacological inhibitors of TRPV1 or 4 channels reduce sprouting angiogenesis, although they are ineffective in reducing VEGF-induced sprouting, suggesting that these channels are not required for the vascular factors effect (O'Leary et al., 2019)

Additionally, these studies will provide unequivocal arguments for the independent and causal relationship between hyperhomocysteinemia and atherothrombotic disease