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Large doses may trigger hormonal changes or alter skin bacteria, leading to pimples or worsening of existing acne

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50mg produces approximately 4050% enzyme inhibition, while 100mg achieves 6075% inhibition, but the curve plateaus beyond 150mg, suggesting diminishing returns

If you compare it to what we see with GLP-1/GIP therapy, the gap is obvious (more on that below)

Importantly, these fat-reducing effects occurred without changes in lean tissue mass, suggesting selective targeting of adipose tissue