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HGH (recombinant GH) supplies exogenous GH directly (bypassing hypothalamic/pituitary control), producing higher circulating GH levels but without restoring physiological pulsatility

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Interestingly, co-culturing IGF-I +/+ osteoclast precursors (spleen cells from WT mice), with IGF-I / osteoblasts (bone marrow stromal cells from IGF-I KO mice), produces significantly fewer (by 90%) multi-nucleated osteoclasts than coculturing IGF-I +/+ osteoclast precursors with IGF-I +/+ osteoblasts, suggesting that osteoblasts may be a source of IGF-I to promote osteoclastogenesis

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Others have unusually vivid dreams that disturb their sleep quality