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Pregnancy, breastfeeding, hypothyroidism, and some pituitary tumors raise prolactin levels and thereby reduce fertility

Gene Expression Modulation Pickart et al

Moreover, other specialized mitochondria-residing proteins, such as the apoptosis inducing factor (AIF) and endonuclease G, are translocated to the nuclei following their release from mitochondria and promote peripheral chromatin condensation and high molecular weight DNA fragmentation