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In a chronic stress scenario, indeed, norepinephrine and cortisol overproduction can activate microglia and mast cell trough NLRP3 inflammasome, with release of pro-inflammatory cytokines, such as IL-1 and TNF-, and Reactive Oxygen Species (ROS) [55], causing neuroinflammation and depression [56]

DIO1 and DIO2 are in charge of the activation of the thyroid hormones T4, T3 and rT3

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Additionally, ChaC2 E74Q/E83Q active site mutants exhibit a closed conformation, regulating the degradation activity of ChaC2 to GSH (20)

doi: 10.1038/s41569-020-0340-9 187 LinRZImGBLuoACZhuYHongXNeumeyerJet al

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