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This understanding of HIF-1s versatility and complexity provides valuable insights into the development of therapeutic strategies targeting this pathway for the treatment of inflammation-related diseases

Since peripheral arteries have relatively more smooth muscle cells than collagen fibers [48], brachial PWV and leg PWV are more responsive to NO-mediated vasodilation than the aorta [50,51]

Nitric oxide synthase in cardiac sarcoplasmic reticulum

Glutathione also participates in gene expression regulation processes, signal transduction, DNA and protein synthesis regulation, as well as proteolysis [82,83], cellular proliferation including lymphocytes and intestinal epithelium cells [37,73,84], apoptotic processes regulation, cytosine production [38,49,85], protein glutathiolation [49,74], regulation of mitochondrial integrity and functioning [39,73,86]

doi: 10.1016/j.ajme.2017.09.001