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1835 : Karl Adolph von Basedow , a German physician at Merseburg Hospital, independently describes the same clinical syndrome, which is why the disease is also known as Basedows disease in many European countries

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Furthermore, a proof-of-concept in vivo study in diet-induced obese mice to test the hypothesis that the most potent inhibitor when administered systemically, would reverse obesity by causing substantial loss of body weight and adiposity without causing any observable adverse effects was conducted

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