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Int J Mol Med 47(5):19 Shino H, Hasuike A, Arai Y, Honda M, Isokawa K, Sato S (2016) Melatonin enhances vertical bone augmentation in rat calvaria secluded spaces

4,6,7 Opioid replacement therapy not only mitigates these changes in neurotransmitters but is also associated with apoptosis, white and grey matter injury, altered redox homeostasis, and changes in oligodendroglial maturation and myelination, which may be particularly damaging in the developing brain