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Dihexa is studied in laboratory models involving HGF/c-Met pathway signaling, neurotrophic activity, synaptogenic response systems, neuronal communication, dendritic spine formation, and CNS cellular pathway behavior

CMS attempted to phase out expenditure authority for DSHP in Section 1115 Demonstrations in 2017 and in 2022, limited the size and scope of DSHP with required state contributions, a cap on the total amount of federal and state DSHP expenditure authority, and time limits for federal funds

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Therefore, considering a broad spectrum of effects that may result from the induction of NO synthesis, a deep analysis of its interaction with potent drugs affecting NO pathways should be performed (e.g., aspirin that has been shown to inhibit eNOS [57])