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Once inside, the unprotonated amphetamine molecules become rapidly protonated by the acidic environment of the vesicle, which alkalinizes the vesicle matrix and completely dissipates the necessary pH gradient (Wimalasena 2011)(see Figure 2 Mechanism A)

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Together, these data demonstrate that ablation of GSH synthesis in mice results not only in reduced expression of lipogenic enzymes but also lower levels of their corresponding lipid species

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Solvent effects were included using a polarizable continuum model (PCM)

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