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Ethics declarations Ethics approval and consent to participate We have referenced pilot studies using biological tissue obtained from male Wistar rats, performed according to local ethics committee and UK Home Office guidelines under the 1986 Scientific Procedures Act

is supported by NIH R35GM122455 and is an Investigator of the Howard Hughes Medical Institute

After consulting the U.S

doi: 10.3389/fphys.2025.1584195 Received 27 February 2025 Accepted 21 May 2025 Published 01 July 2025 Volume 16 - 2025 Edited by Walter Swardfager, University of Toronto, Canada Reviewed by Andrea Deledda, Azienda Ospedaliero-Universitaria Cagliari, Italy Natasha Anita, University of California, San Diego, United States Updates Copyright 2025 Hinman, Alan and Lee

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