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For example, HIF1 inhibitors may overcome hypoxia-induced resistance by blocking BNIP3L-mediated mitophagy ( 2.4.2 Potential of combination therapy strategies Combination therapy strategies have emerged as a promising avenue in overcoming resistance

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Collectively, these Pharmacophore characteristics support the hypothesis that NAC can act as a molecular stabilizer, counteracting Crystallin unfolding and aggregation processes that drive age-related lens opacity, thereby positioning NAC as a promising therapeutic candidate for anti-cataract intervention 106

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Given the significant reduction in intracellular GSH, and induction of its canonically partnering stress response, we asked whether this impacted intracellular selenoprotein abundance in the CNS