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Furthermore, one should note that only small fractions of the measured pools of glutamate and GABA are involved in neurotransmission

After being synthesized from glucose in astrocytes, L-serine is shuttled to neurons to fuel the synthesis of D-serine, and the serine shuttle mechanism adds to other possible forms of metabolic interchange between astrocytes and neurons (Wolosker and Radzishevsky, 2013)

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Those medications have undergone extensive testing and are regulated by the FDA

A 500-person multi-center trial is currently ongoing (Adelman 2014)

3.2.1 Pathophysiology of oxidative stress Oxidative stress can be induced by free radical production