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This was also the first report supporting sVEGFR-2 as a positive marker after treating metastatic GC with the combination of paclitaxel and ramucirumab

Oxidative-stress-induced intestinal permeability is thought to be mediated through the tyrosine phosphorylation of occludin and the redistribution of occludin, ZO-1, E-cadherin, and -catenin from the intracellular junctions 76,77

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Measure what you can, tweak as needed, and embrace the messiness of real life