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We propose a novel GOF test for meta-analysis that utilizes the pivotal quantity (PQ) methodology proposed for Bayesian model assessment 10, 11 , and adapts the Cauchy combination test 12 , which combines dependent p values computed using posterior draws from Markov chain Monte Carlo (MCMC), to inform the final conclusion

Statements Author contributions MS: Writing review & editing, Writing original draft

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These conditions are associated with high fatality and significant burden on the health system in terms of direct costs of treatment ( Since it was first reported in 2005 ( HLA-B*58:01 allele is significantly associated with increased risk of developing SJS/TEN in patients using allopurinol ( HLA-B*58:01 was positive, which confirmed allopurinol as the causative drug of SJS/TEN