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10.1016/j.cmet.2023.11.017 162 WeiX.HuangQ.HuangJ.YuL.ChenJ

For comparisons involving three or more groups with a single variable, a one-way ANOVA was employed

Mechanistically, oxidative stress triggers endoplasmic reticulum stress through the activation of the PERK-eIF2-ATF4 and IRE1-XBP1 signaling pathways, as well as through the upregulation of CHOP (C/EBP homologous protein), which promotes apoptotic signaling (75) as shown in Figure 4