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Effect of glutaurine on plasma renin activity in the rat and the dog

7 Compared with placebo, patients taking metformin had an increased risk of vitamin B 12 deficiency (number needed to harm = 14 per 4.3 years) and low vitamin B 12 levels (number needed to harm = 9 per 4.3 years)

10.1111/j.1742-7835.2007.00020.x

The full picture of whats actually happening inside your body goes much deeper than the number alone

doi:10.1385/1-59259-274-0:195

It should be noted that the use of yeast extract in skin-care products is comparatively new and still restricted, and in addition, there are relatively few research reports on this area, so there is great potential for development of new applications and products