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This excess of lactate is secreted in the extra cellular environment where it diffuses and is picked up by the more oxygenated cells which internalise the lactate in the cytoplasm, revert it to pyruvate and use it to further enhance the efficiency of their TAC and, consequently, of their oxidative phosphorylation

References Hackett AM, Koester SW, Rhodenhiser EG, Scherschinski L, Rulney JD, Naik A, Nico E, Eberle AT, Hartke JN, Fox BM, Winkler EA, Catapano JS, Lawton MT

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Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed using The Database for Annotation, Visualization, and Integrated Discovery (DAVID) 48

Gene Expression and Cellular Regulation Some vitamins directly influence gene expression and cellular differentiation