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Tieliu Shi, [email protected] This article was submitted to Translational Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Positive ANA titers were found in up to 70% of morphea patients, being associated with a higher risk for extracutaneous, deeper involvement and disease relapse (1, 2, 16, 26, 96, 100)