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While insomnia is not listed among common adverse reactions in FDA prescribing information or major clinical trials, some patients report sleep disturbances during treatment

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Cruysberg JR, Wevers RA, van Engelen BG, Pinckers A, van Spreeken A, Tolboom JJ

Ideally, all UC patients should be offered a combination of oral and enema 5-ASA[1]

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Dyspepsia, characterized by upper abdominal discomfort, early satiety, or postprandial fullness, may affect a similar proportion of patients and can contribute to reduced caloric intake and weight loss, though it may also impact quality of life if severe or persistent