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In: Handbook of Targeted Cancer Therapy

4.3 VITAMIN B12 IN OVO-LACTOVEGETARIANS Ovo-lacto vegetarians should also take supplements as a precaution, as it is very likely that they do not consume adequate amounts every day

M., Elizondo-Luvano, J

Apart from exacerbating local inflammation, TNF- can activate the NF-KB and MAPK signaling pathways, increasing cellular susceptibility to oxidative stress and weakening GPX4 and other antioxidant enzymes, thereby promoting further accumulation of lipid peroxidation byproducts and markedly elevating ferroptosis risk (119)