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This kind of protection-damage dynamic transformation can well explain the phenomenon of the bilirubin paradox in PD (Moccia et al., 2015

Additionally, exposure of erythrocytes to heavy metals, pollutants, and xenobiotics triggers eryptosis through various mechanisms of cell death

Cell Chem Biol (2017) 24(1):8797

After stopping a CYP3A4 inducer, as the effects of the inducer decline, codeine plasma concentrations may increase, with subsequently greater metabolism by cytochrome CYP2D6, resulting in greater morphine levels [see CLINICAL PHARMACOLOGY], which could increase or prolong both the therapeutic effects and adverse reactions, and may cause serious respiratory depression

In addition, in the production of ROS by leukocytes, as in thyrocytes, the key enzyme is peroxidase

Droog et al., 1995)