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doi:10.1016/j.autrev.2009.02.020 Bravenboer B, Kappelle AC, Hamers FP, van Buren T, Erkelens DW, Gispen WH

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This increase in arginine levels in the mutant exposed to iron directly correlates with the decrease in the abundance of the repressor ArgR, which could be regulating the arcA genes (EF0104, encoding arginine deiminase), arcF (EF0105, encoding ornithine carbamoyltransferase) and argC (encoding carbamate kinase), all of which are derepressed in the mutant compared to the WT

74 The difference in regard to visceral, hepatic adiposity, hypoadiponectinemia, the insulin-sensitizing hormone-adiponectin, resting energy expenditure, 67,75,76 lipid metabolism 77 may also contribute to higher IR in male compared with female

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