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Intersection analysis using a Venn diagram of RA-related, gut microbiota-related, and ferroptosis-related genes identified, for the first time, 16 genes potentially mediating RA pathology and involved in gut microbiota metabolism and ferroptosis (EGFR, MAPK8, NQO1, APOE, TGFB1, LCN2, HMOX1, NR1H4, PLIN2, PTGS2, CDKN1A, IL6, FFAR2, GPX3, JUN, and MYC)

Lengyel, E., Makowski, L., DiGiovanni, J

McInnes, I

The current study shows that treadmill exercise (6 days/week, 4 weeks)-induced endothelial Krppel-like factor 2 (KLF2) expression enhances endothelial NOS (eNOS) activity via stimulating the PI3K-Akt pathway and heat-shock protein 90 (Hsp90) [47]

These factors precluded statistical pooling of effect sizes or reliable subgroup comparisons

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