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Follow established laboratory handling procedures and appropriate research protocols when preparing or evaluating this material

(Even a few months of high-dose continuing steroid can cause bone loss.) Patients are advised to get adequate calcium/vitamin D, and periodic bone density monitoring is prudent

Exogenous Trx and intracellular Trx combine with MIF to form a complex which affects the MIF-induced inflammatory response

Homocysteine Lowering Trialists' Collaboration

Nat Med (2015) 21(8):88794

Investigators proceeded with supplementation with folic acid (350 to 1,000 g daily by mouth) and vitamin B12 (1,000 g IM every 9 weeks) in 220 patients receiving chemotherapy with pemetrexed disodium