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A molecular classifier trained on histologic rejection vs no rejection in biopsies predicted molecular rejection with AUC=0.87 but histologic rejection less well (AUC=0.65, Fig1E)

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doi: 10.1016/j.freeradbiomed.2014.02.003 57 CarnesecchiSPacheJCBarazzone-ArgiroffoC

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In sum, ketones confer a two-fold therapeutic advantage in the setting of nutrient competition

Specifically, GHK-Cu suppresses transcriptional programs associated with cellular senescence while enhancing expression of genes linked to DNA repair, proteostasis, and metabolic resilience