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The ideal ratio of omega-6/omega-3 PUFAs in the diet is 1.52: 1, however, when it is higher than 1.52:1, it would lead to a decrease in hormone levels, which in turn affects reproductive performance (7)

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While CBP/p300 is a well-validated direct interaction partner of NRF2 with prominent functions at enhancers, we report that this interaction is not required for NRF2-dependent NSCLC cell growth, indicating that NRF2 can sustain sufficient transcriptional activity in the absence of CBP/p300 coactivation

Interestingly Hua Han et al., recently have reported many synthesized derivatives from picroside-II and demonstrated the hepatoprotective activity of the derivatives evaluated on SMMC-7721 cells [84]