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Therefore, it is essential to thoroughly validate mouse findings in humanized models, like patient-derived iPSC 3D brain organoids, to ensure they are applicable to humans

Glyoxylate and dicarboxylate metabolism is closely linked to TCA cycle and photorespiration

ABCB4 mutations, involved in PFIC3, ICP, and LPAC syndrome, have mostly missense variants in heterozygosity in patients with late-onset diseases

Down-regulation of a hepatic transporter multidrug resistance-associated protein 2 is involved in alteration of pharmacokinetics of glycyrrhizin and its metabolites in a rat model of chronic liver injury

Note that pregnancy often causes lower histamine levels, and allergies often subside during pregnancy

Practical resources and next steps Want to learn more about research-backed approaches