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The use of microbiome-based interventions in early symptomatic individuals may modulate ongoing neuroinflammatory processes and slow down or delay disease risk or progression (54, 96)

Fungal Toxins and Host Immune Responses.Frontiers in Microbiology

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Kumar et al

As expected, mutation of Lys251 to Gln led to complete loss of IDH2 activity, demonstrating the importance of these active site residues