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We recognize that certain patients clearly fulfill the classic criteria of FMS and have a very pronounced central nervous system (CNS) dysfunction of unknown origin that causes abnormal central processing of sensory stimuli

8 GSH is the brains primary tool for neutralizing that internal pollution, alongside external stressors like environmental toxins and pollutants that reach the brain and add to its overall oxidative load

While it is perhaps somewhat surprising that no group differences in metabolite concentrations were found, either for GABA (as has been shown before) or for GSH, we note that autism is an extremely heterogeneous condition, and that group differences, if present, may be small and relatively uninformative in understanding the broader autism phenotype(Loth et al., 2021)

Phenformin was well tolerated up to high concentrations, which agrees with its previous use as an antidiabetic drug before it was withdrawn from the market in the 1970s due to more frequent fatal cases of lactic acidosis compared to the alternative antidiabetic metformin

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Adv Funct Mater, 2021, 31: 2106079 Jiang F, Ding B, Liang S, et al