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49 Apart from polymeric nanoparticles, inorganic nanoparticles have also been extensively investigated for their biomedical applications

The level of lipid peroxidation was determined by imaging of the stained cells using an UltraVIEWVoX double spinning disk confocal microscope (PerkinElmer Life Sciences) or by flow cytometry analysis

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Critically, glutathione (GSH), the major non-enzymatic antioxidant and redox regulator, was decreased in the cerebrospinal fluid and prefrontal cortex in vivo 8 and in postmortem tissue samples 9 and was associated with negative symptoms 10 in schizophrenia

The antibody-drug conjugate according to claim 1, wherein D is a moiety of formula (III)whereinX is C or N, preferably N;Ring A is a heterocycloalkyl having 3 to 10 ring atoms, or a heteroaryl having 5 to 10 ring atoms, said heterocycloalkyl and heteroaryl being optionally substituted, preferably by one or more substituent selected from -OH, =O, C 1 -C 12 alkyl, C 1 -C 12 heteroalkyl, C 3 -C 6 cycloalkyl, heterocyclyl having 5 to 10 ring atoms, aryl having 6 to 10 ring atoms, heteroaryl having 5 to 10 ring atoms, -(C 1 -C 12 alkyl)-(C 3 -C 8 cycloalkyl), -(C 1 -C 12 alkyl)-(heterocycloalkyl having 3 to 10 ring atoms), -(C 1 -C 12 alkyl)-(heteroaryl having 5 to 10 ring atoms), -(C 1 -C 12 alkyl)-(aryl having 6 to 10 ring atoms), and -NR'R"