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Medizinische Monatsschrift fur Pharmazeuten 2014;37:299

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-MSH emerged as a promising novel anti-obesity drug, and intranasal administration of the melanocortin sequence MSH/ACTH4-10 to normal-weight subjects was shown to acutely increase subcutaneous WAT lipolysis (27) and decrease body fat by 1.7 kg, when administered for six weeks (28)

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IGF-binding protein 1 and abdominal obesity in the development of type 2 diabetes in women

Yet in practice, they produce completely different outcomes for completely different purposes, and choosing the wrong one means months of wasted effort targeting the wrong mechanism entirely