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tells the Mayo Clinic, Low levels of B-12 and other B vitamins such as vitamin B-6 and folate may be linked to depression. Studies may be inconclusive, but at the very least, a holistic and integrated approach to ones health in the form of adequate vitamins and nutrients helps achieve a more balanced biology that certainly wont hurt your overall mood

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However, supplementing excessively high levels of B12 can have some adverse effects

Other Biological Oxidations Oxidase complexes, like cytochrome oxidase, transfer electrons directly from NADH and other substrates to oxygen, producing water