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Therefore, we examined in first proof-of-principle studies whether pharmacological inhibition of the IL-1R/TLR-signaling associated IRAK4 kinase alleviates pulmonary inflammation and affects the recruitment of neutrophils and MoAM upon acute and sub-chronic smoke exposure ( Figure 8A )

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When Labour leader Hugh Gaitskell died in January 1963, Wilson won the leadership election to replace him, becoming Leader of the Opposition

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