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Aberrantly glycosylated IgG elicits pathogenic signaling in podocytes and signifies lupus nephritis

Thus, mtDNA methylation has been proposed as one mechanism for regulating mitochondrial activity

Thus, CYPs play a key role in cellular processes, taking part in the synthesis of cholesterol, bile acids, sex hormones, and corticosteroids, as well as in blood homeostasis, immune response, and detoxification from potentially harmful xenobiotics [3, 4]

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Resident immune and parenchymal cells respond promptly to the presence of a microorganism through the activation of PRRs and secretion of pro-inflammatory and antimicrobial cytokines, such as type I interferons

Our results for the first time demonstrate that biallelic variants in BBOX1 cause a clinical and biochemical phenotype that is consistent with a deficiency in endogenous carnitine synthesis