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Metabolism Based on an oral 14C-orlistat mass balance study in obese patients, two metabolites, M1 ((the hydrolyzed -lactone ring product of orlistat) and M3 (sequential metabolite after M1's cleavage of the N-formyl leucine side-chain), accounted for approximately 42% of total radioactivity in plasma

Data were analyzed based on the distribution of cell populations in different phases of cell cycle

We postulate that boosting mitochondrial metabolism might be a potential therapeutic strategy to induce antidepressant effects

10.1073/pnas.1102281108 39 DeBerardinisR