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Oxidative stress, the paradigm of ozone toxicity in plants and animals

doi: 10.1038/s41387-020-00141-0 169

Dolganiuc A, Petrasek J, Kodys K, Catalano D, Mandrekar P, Velayudham A

Since previous studies have linked the activation of NRF2 with the repression of lipogenic gene expression 64 , we reasoned that GSH depletion causes oxidation and consequent inactivation of KEAP1 (a repressor of NRF2), thus leading to increased antioxidant and decreased lipogenic gene expression