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Clinicians must also consider pre-existing low serum copper: repeated high-dose zinc infusions accelerate enteral metallothionein expression, sequestering dietary copper and precipitating secondary hypocupremia that manifests as anemia and neutropenia

Large doses of vitamin B 6 (pyridoxine) should be avoided to prevent the peripheral conversion of levodopa (L-dopa) to dopamine, which interferes with the efficacy of L-dopa therapy

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