l'glutathione sulfur Structures of studied sulfur-donor ligands PURCELL 5% L-Glutathione (88B/mL) Face

10.1038/s41392-025-02145-7 67 KaliaL

This degeneration of dopaminergic neurons is strongly linked to the generation of reactive oxygen species and oxidative stress as well as mitochondrial dysfunction, neuroinflammation, and aging (Dias et al., 2013)

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Recent advances in neuroimaging technology allowing for in vivo quantification of GSH levels in the brain have shown decreased GSH in patients with MS compared to healthy controls, with the degree of depletion correlating with disease severity and showing parallel longitudinal decline over time (Choi et al., 2018

Miro1 possesses multiple lysine residues that undergo ubiquitination, and impairment of Miro1 ubiquitination hinders the translocation of E3 ubiquitin ligase Parkin (Lpez-Domnech et al., 2021), leading to delayed mitophagy in response to damaged mitochondria (Gupta et al., 2022

Cicek B, Danisman B