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Poly (A)-specific ribonuclease (PARN): More than just mRNA stock clearing

M., Noraldeen, S

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49 In patients with ARDS, dysregulation of lipid metabolism contributes to the inflammatory response and regulation of ROS, promoting inflammation and lung injury (Figure 2)

Notably, the IDH-mutant glioma we tested also contained quiescent AC-like glioma cells that were selectively depleted by RSL3, although effects on the metabolic signatures were different, suggesting that sensitivity to ferroptosis is mechanistically distinct in IDH-mutant gliomas, possibly related to the effects of the IDH-mutation on cellular metabolism (Karpel-Massler et al, 2017