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5-Amino-1MQ (5-amino-1-methylquinolinium) is the most studied inhibitor of nicotinamide N-methyltransferase (NNMT) an enzyme that acts as a metabolic brake in fat cells by depleting both SAM (S-adenosylmethionine) and NAD+ precursors

Thrombocytosis: Dangerous Increase in Blood Platelets B12 replacement therapy can trigger significant thrombocytosis (excessive production of platelets, the blood cells responsible for clotting)

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It also helps to slow the emptying of the stomach, leading to prolonged feelings of fullness

This increases actual concentration slightly a 53mg vial reconstituted with 2mL yields 26.5mg/mL instead of 25mg/mL