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Uncontrolled free-radical damage is a key cause in diseases affecting the brain, including schizophrenia and Alzheimers

Contingent to the number of carboxylic groups and dissociation properties, OAs can carry varying negative charge, thereby allowing the complexation of metal cation in solution and displacement of anions from the soil-matrix (Jakkeral and Kajjidoni, 2011)

doi: 10.1016/j.intimp.2023.110651 171 YaoXLiC

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Regarding diabetic nephropathy, results of studies on diabetic rats showed that ALA exerts a strong protective effect on diabetic kidneys [65] and that oral ALA supplementation is able to prevent early development and progression of diabetic nephropathy acting as an anti-hyperglycemic, antioxidant, anti-inflammatory, anti-fibrotic and anti-apoptotic compound [66]