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The presurgical visit occurred approximately 1 month before the DBS surgery, whereas the post-surgical visits occurred at 1, 3, 6 and 12 months after surgery

In selected experiments, changes in the intracellular Fe pool were independently validated via the use of a BioTracker 575 Red Fe Dye (Merck), a highly specific fluorescent sensor that increases in signal intensity upon binding to Fe

Hence, the delivery of drugs to the brain has gained more and more interest

Oxalate crystals can accumulate in the joints, skin, vasculature, and even the brain leading to inflammation, mitochondrial dysfunction, and cell damage

Mulvihill et al., 2011

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