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In enzymes, tyrosine residues are often associated with active sites, alteration of which can change enzyme specificity or wipe out activity entirely

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Several groups have successfully explored albumin-based drug delivery using Cys 34 as a chemical conjugation approach, such as Abraxane, the first albumin-based drug approved in oncology (100102)

Constitutively active APC/C CDH1 targets PIN1 and other mitotic proteins for degradation to provoke cell cycle exit APC/C CDH1 E3 ligase activity is frequently inhibited in cancer cells, likely due to hyperphosphorylation of CDH1 induced by increased CDKs activity, resulting in decreased APC/C CDH1 activity 9,14,42

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