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The vigorous use of diuretics usually increases magnesium loss, and high levels of calcium intake (and therefore calcium excretion) tend to increase magnesium excretion

Podgrska, A., Pucion-Jakubik, A., Markiewicz-ukowska, R., Gromkowska-Kpka, K.J

Monitoring-guided supplementation is the usual approach, typically beginning with oral supplementation if blood tests indicate suboptimal levels, and escalating to IM injection if oral treatment is insufficient or poorly tolerated

In humans, B12 deficiencies are seen more commonly in people consuming a vegetarian or vegan diet who are not supplementing enough B12

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Total plasma cholesterol was also lower