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Mayo Clinic Proceedings: Innovations, Quality & Outcomes

Clin Oncol

1 Smurf1 interacts with PDK1 and activates Akt signaling

Warnings: Consult your healthcare professional before use if pregnant, nursing, or taking medication

It also inhibits MPTP-induced oxidative stress in the substantia nigra of subacute Parkinsons mice by regulating the Nrf2/HO-1/NAD(P)H:quinone oxidoreductase 1 (NQO1) signaling pathway, thus preventing dopaminergic neuron apoptosis and improving both exercise ability and anxiety behavior in mice (He and Bian, 2022)