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Despite these global prevalence figures, and the fact that SCD is by far the largest public health concern among the hemoglobinopathies, it was not until 2006 when the World Health Organization (WHO) recognized SCD as a global public health problem 1

Combination nutraceuticals Metanx : Metanx is a prescription medical food containing L-methylfolate, methylcobalamin, and pyridoxal-5-phosphate

doi: 10.1016/j.biopha.2021.111309 19

on the other hand, it promotes microglial polarization toward an M2 phenotype and inhibits M1 polarization, thereby suppressing inflammation-induced apoptosis and fostering neuronal regeneration (Qian et al., 2024