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Extraneural locations such as the skin, bones, and viscera have also been reported

Am J Surg Pathol 1995

The FDA does not verify the safety or effectiveness of compounded drugs

Because nausea and flushing are the dominant barriers to continuation, the practical reality is that starting exposure and titrating to effect and tolerance, where clinically appropriate, can determine whether a patient stays on therapy at all one of the advantages clinicians cite for adjustable compounded preparations over a single fixed dose

Mt Sinai J Med

Nonpsammomatous MS is considered to be a sporadic type and commonly affects spinal nerves and paraspinal ganglia, whereas psammomatous type often involves autonomic nerves of viscera