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338 Multiple controlled clinical trials and meta-analyses have shown saffron extract, typically at a dose of 30 mg per day, is more effective than placebo and comparable to antidepressant drugs for improving mild-to-moderate depression

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There are specific, documented cases where a qualified dermatologist might consider it: severe and resistant pigmentation conditions, including certain presentations of melasma that have not responded adequately to topical treatments, oral supplements, and professional procedures over an extended period

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The results suggested a beneficial impact in various chronic disease states, particularly when inflammation and/or oxidative stress contributed to the pathophysiology ( (see sections 1.2.2 Pharmacodynamics, 4.1 Absorption into plasma/serum and concentration profiles, 5 Biodistribution, and 6.1 Pre-systemic metabolism: role of gut microbiota)

Effect of middle cerebral artery occlusion on mRNA expression for the sodium-coupled vitamin C transporter SVCT2 in rat brain